All clinical trials with Circadin included patients with hypertension and/or cardiovascular diseases as the insomnia patient population is quite enriched with such comorbidities41.
Circadin® was found safe and effective in such patients (data on file). In a study in patients with nocturnal hypertension Circadin® significantly improved nocturnal blood pressure42 in a meta analysis of published studies it was found that only controlled release melatonin preparations are beneficial in alleviating nocturnal hypertension whereas fast release formulations are not efficacious16. Reduction innocturnal hypertension is of major importance in the prevention of cardiovascular and cerebrovascular morbidity.
Circadin® was found safe and effective in such patients (data on file). In a study in patients with nocturnal hypertension Circadin® significantly improved nocturnal blood pressure42 in a meta analysis of published studies it was found that only controlled release melatonin preparations are beneficial in alleviating nocturnal hypertension whereas fast release formulations are not efficacious16. Reduction innocturnal hypertension is of major importance in the prevention of cardiovascular and cerebrovascular morbidity.
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