Circadin® is safe and is not associated with any of these adverse effects. Furthermore, Circadin® shortens sleep latency to the same extent as most of the ‘z’-drugs but, in addition and unlike BZDs and ‘z’-drugs, Circadin® improves the restorative value of sleep which translates into improved quality of sleep, daytime functioning, and quality of life34 29 31 30.
The use of other sedative hypnotics, such as BZDs have been associated with rebound insomnia, dependence, and neuropsychiatric reactions such as hostility and depression. Also, although effective in getting patients to sleep, these hypnotics further disrupt sleep architecture and structure – primarily by reducing ‘deep sleep’ (NREM stages 3 and 4) as well as well as REM stages of sleep36 37, a phenomenon that may impair memory consolidation.
In addition, the use of sedative hypnotics has been associated with road traffic accidents and a higher risk of falls8 38, especially in the elderly population.
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