Cochrane review (Herxheimer & Petrie, 2002) demonstrated a good effect of melatonin in treating the symptoms of jet lag50. One study (Suhner et al., 1998) found that a slow-release formulation of melatonin was somewhat less effective than immediate-release melatonin51 but recent studies showed that fast and controlled release formulation are equally potent in phase shifting 52.
The effect of Circadin® on jet-lag has not been studied in a clinical trial.
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