Clinical relevance of Circadin use

Circadin.com February 13, 2022
Circadin® provides good quality natural sleep for patients, offering an effective and safe treatment for their sleep problems. unlike old common hypnotics sedative treatments (like Zolpidem). Sleep quality, even more than sleep latency, impacts morning alertness and quality of life of patients. Circadin® is the only sleep drug that improves both sleep quality and daytime functioning 62 1 .

Circadin’s® patented formulation mimics the natural melatonin profile by releasing melatonin gradually over 8-10 hours, which results in a restorative and natural sleep. Patients gain good sleep quality and subsequently improved daytime functioning without the residual feeling in the morning following the old hypnotic intake. Circadin® is not a CNS-depressant hypnotic and does not bind to GABAA receptors, which are associated with anxiolytic, myorelaxant, and amnesic effects 60 1 62 .

Apart from the risk of dependence, ‘z’-drugs such as zolpidem and zopiclone have been associated with residual sedative effects, marked rebound insomnia, strange behaviour at night, anterograde memory disturbances and an increased risk of falls8 32 33. In contrast, Circadin® does not cause impairment of cognitive skills or a negative effect on next-morning vigilance34 35. In fact, in clinical trials, Circadin® improved morning alertness and functioning30 31 12. Circadin® does not alter sleep architecture, and there is no evidence of increased risk of falls, dependence, rebound or withdrawal effects34 31 30. Furthermore, Circadin® shortens sleep latency to the same extent as the ‘z’-drugs34 30 29. Unlike zolpidem and the other hypnotics, Circadin® improves quality of sleep, daytime functioning, and quality of life30 31 34 12.

Posted in: Clinical relevance

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