When is it recommended to take Circadin® before bedtime? Circadin® and food intake?

The recommendation according to SPC (Summary of Product Characteristics) is as follows:
“The recommended dose is 2 mg once daily, 1-2 hours before bedtime and after food”¹.

In the PK studies a meal was served 1/2 an hour before drug administration – the meal was not big and contained fat. The patients were instructed to have a light meal before (30 minutes) they take Circadin^®. If Circadin^® is ingested on an empty stomach it will have a somewhat faster release.