Circadin pivotal studies

Efficacy of prolonged release melatonin in insomnia patients aged 55–80 years: quality of sleep and next-day alertness outcomes
Alan G Wade, Ian Ford, Gordon Crawford, Alex D McMahon, Tali Nir, Moshe Laudon and Nava Zisapel

Prolonged-release melatonin improves sleep quality and morning alertness in insomnia patients aged 55 years and older and has no withdrawal effects
Alan Wade, Nava Zisapel, Patrick Lemoine